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Article

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.

Molecular and cellular biology - 1 Aug 2005

Chan Denise A, Sutphin Patrick D, Yen Shing-Erh, Giaccia Amato J

Abstract excerpt

Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline that is hydroxylated in the presence of oxygen, allowing the von Hippel-Lindau (VHL) E3 ubiquitin ligase to interact...

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Source

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Identifiers

PMID: 16024780
DOI: 10.1128/MCB.25.15.6415-6426.2005
PMCID: PMC1190339

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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