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Insights into the proline hydroxylase (PHD) family, molecular evolution and its impact on human health.

Biochimie - 1 Sept 2015

Minervini Giovanni, Quaglia Federica, Tosatto Silvio C E

Abstract excerpt

PHDs (proline hydroxylases) are a small protein family found in all organisms, considered the central regulator of the molecular hypoxia response due to PHDs being completely inactivated under low oxygen concentration. At physiological oxygen concentration, PHDs drive the degradation of the HIF-1α (hypoxia-inducible factor 1-α), which is responsible for upregulating the expression of genes involved in the...

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PMID: 26187473
DOI: 10.1016/j.biochi.2015.07.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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