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Article

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.

Science (New York, N.Y.) - 7 Jun 2002

Min Jung-Hyun, Yang Haifeng, Ivan Mircea, Gertler Frank, Kaelin William G, Pavletich Nikola P

Abstract excerpt

The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability. pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent. The 1.85 angstrom structure of a 20-residue HIF-1alpha peptide-pVHL-ElonginB-ElonginC complex shows that HIF-1alpha...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12004076
DOI: 10.1126/science.1073440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.PMID 12004076Read ↗

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