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Article

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2004

Kageyama Yukio, Koshiji Minori, To Kenneth K W, Tian Ya-Min, Ratcliffe Peter J, Huang L Eric

Abstract excerpt

Hypoxia-inducible factor (HIF)-1alpha, a master regulator of oxygen homeostasis, regulates genes crucial for cell growth and survival. In normoxia, HIF-1alpha is constantly degraded via the ubiquitin-proteasome pathway. The von Hippel-Lindau (VHL) E3 ubiquitin ligase binds HIF-1alpha through specific recognition of hydroxylated Pro-402 or Pro-564, both of which are modified by the oxygen-dependent HIF prolyl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15084514
DOI: 10.1096/fj.03-1233fje

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.PMID 15084514Read ↗

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