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Article

Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.

The Journal of biological chemistry - 3 Apr 2009

Furlow Paul W, Percy Melanie J, Sutherland Scott, Bierl Charlene, McMullin Mary Frances, Master Stephen R, Lappin Terence R J, Lee Frank S

Abstract excerpt

A classic physiologic response to hypoxia in humans is the up-regulation of the ERYTHROPOIETIN (EPO) gene, which is the central regulator of red blood cell mass. The EPO gene, in turn, is activated by hypoxia inducible factor (HIF). HIF is a transcription factor consisting of an alpha subunit (HI...

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Identifiers

PMID: 19208626
DOI: 10.1074/jbc.M808737200
PMCID: PMC2666553

Genes

EPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19208626-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.PMID 19208626Read ↗

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