Article
A branch-and-bound algorithm for the inference of ancestral amino-acid sequences when the replacement rate varies among sites: Application to the evolution of five gene families.
Bioinformatics (Oxford, England) - 1 Aug 2002
Pupko Tal, Pe'er Itsik, Hasegawa Masami, Graur Dan, Friedman Nir
Abstract excerpt
MOTIVATION: We developed an algorithm to reconstruct ancestral sequences, taking into account the rate variation among sites of the protein sequences. Our algorithm maximizes the joint probability of the ancestral sequences, assuming that the rate is gamma distributed among sites. Our algorithm probably finds the global maximum. The use of 'joint' reconstruction is motivated by studies that use the sequences at...
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