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Article

Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites.

Molecular biology and evolution - 1 Nov 1993

Yang Z

Abstract excerpt

Felsenstein's maximum-likelihood approach for inferring phylogeny from DNA sequences assumes that the rate of nucleotide substitution is constant over different nucleotide sites. This assumption is sometimes unrealistic, as has been revealed by analysis of real sequence data. In the present paper Felsenstein's method is extended to the case where substitution rates over sites are described by the gamma...

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PMID: 8277861
DOI: 10.1093/oxfordjournals.molbev.a040082

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