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Article

The estimation of relative site variability among aligned homologous protein sequences.

Bioinformatics (Oxford, England) - 22 Mar 2003

Horner D S, Pesole G

Abstract excerpt

MOTIVATION: Maximum likelihood-based methods to estimate site by site substitution rate variability in aligned homologous protein sequences rely on the formulation of a phylogenetic tree and generally assume that the patterns of relative variability follow a pre-determined distribution. We present a phylogenetic tree-independent method to estimate the relative variability of individual sites within large datasets...

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Identifiers

PMID: 12651718
DOI: 10.1093/bioinformatics/btg063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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