Article
A gamma mixture model better accounts for among site rate heterogeneity.
Bioinformatics (Oxford, England) - 1 Sept 2005
Mayrose Itay, Friedman Nir, Pupko Tal
Abstract excerpt
MOTIVATION: Variation of substitution rates across nucleotide and amino acid sites has long been recognized as a characteristic of molecular sequence evolution. Evolutionary models that account for this rate heterogeneity usually use a gamma density function to model the rate distribution across sites. This density function, however, may not fit real datasets, especially when there is a multimodal distribution of...
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