Article
Frequent occurrence of CYP2D6*10 duplication allele in a Japanese population.
Mutation research - 29 Aug 2002
Mitsunaga Yoshiharu, Kubota Takahiro, Ishiguro Akihiro, Yamada Yasuhiko, Sasaki Hiroshi, Chiba Kan, Iga Tatsuji
Abstract excerpt
Allele-specific long-polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism (RFLP) and haplotype analysis using XbaI and EcoRI were used to determine whether gene duplication of CYP2D6*10 exists in a Japanese population of 162 healthy subjects. Based on the results of PCR and haplotype analysis, the frequencies of CYP2D6*1X2, CYP2D6*2X2 and CYP2D6*10X2 in the Japanese population were...
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