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Article

Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6.

British journal of clinical pharmacology - 1 Sept 2003

Ohnuma Tohru, Shibata Nobuto, Matsubara Yoichiro, Arai Heii

Abstract excerpt

AIMS: The cytochrome P-450 2D6 (CYP2D6) gene duplication/multiduplication producing an increase in enzyme activity, and the common Japanese mutation, CYP2D6*10A producing a decrease of enzyme activity were screened in a large number of Japanese psychiatric subjects (n = 111) in order to investigate whether these mutated alleles affected the plasma concentration of haloperidol. METHODS: Polymerase chain...

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Identifiers

PMID: 12919180
DOI: 10.1046/j.0306-5251.2003.01872.x
PMCID: PMC1884346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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