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Article

Cytochrome P450 polymorphisms as risk factors for steroid hormone-related cancers.

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2001

Friedberg T

Abstract excerpt

The development of cancers of the breast, endometrium, ovaries and possibly prostate is modulated by steroid hormones. Many steroids and environmental carcinogens are subject to cytochrome P450 (P450)-mediated metabolism that generates reactive metabolites and modulates steroid potency, thereby influencing tumor initiation and promotion respectively. These pathways, which are modulated by polymorphisms in P450...

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Identifiers

PMID: 12174676
DOI: 10.2165/00129785-200101020-00001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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