Article
Allelic-based gene-gene interaction associated with quantitative traits.
Genetic epidemiology - 1 May 2009
Jung Jeesun, Sun Bin, Kwon Deukwoo, Koller Daniel L, Foroud Tatiana M
Abstract excerpt
Recent studies have shown that quantitative phenotypes may be influenced not only by multiple single nucleotide polymorphisms (SNPs) within a gene but also by the interaction between SNPs at unlinked genes. We propose a new statistical approach that can detect gene-gene interactions at the allelic level which contribute to the phenotypic variation in a quantitative trait. By testing for the association of allelic...
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