Article
Mapping a disease locus by allelic association.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 1998
Collins A, Morton N E
Abstract excerpt
Allelic association provides a means to map disease genes that, in a dense map of polymorphic markers, has considerably higher resolution than linkage methods. We describe here a composite likelihood estimate of location for a disease gene against a high-resolution marker map by using allele freq...
Topics
- Alleles
- Case-Control Studies
- Chromosome Mapping
- Cystic Fibrosis
- Female
- Genetic Linkage
- Genetic Markers
- Genetics, Population
- Haplotypes
- Humans
- Lod Score
- Male
- Models, Biological