Positional cloning by linkage disequilibrium.

doi:10.1086/383589

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Article

Positional cloning by linkage disequilibrium.

American journal of human genetics - 1 May 2004

Maniatis Nikolas, Collins Andrew, Gibson Jane, Zhang Weihua, Tapper William, Morton Newton E

Abstract excerpt

Recently, metric linkage disequilibrium (LD) maps that assign an LD unit (LDU) location for each marker have been developed (Maniatis et al. 2002). Here we present a multiple pairwise method for positional cloning by LD within a composite likelihood framework and investigate the operating charact...

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