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Article

A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions.

Oncogene - 22 Aug 2002

Inga Alberto, Nahari Dorit, Velasco-Miguel Susana, Friedberg Errol C, Resnick Michael A

Abstract excerpt

A mutation in codon 122 of the mouse p53 gene resulting in a T to L amino acid substitution (T122-->L) is frequently associated with skin cancer in UV-irradiated mice that are both homozygous mutant for the nucleotide excision repair (NER) gene Xpc (Xpc(-/-)) and hemizygous mutant for the p53 gene. We investigated the functional consequences of the mouse T122-->L mutation when expressed either in mammalian cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12173040
DOI: 10.1038/sj.onc.1205779

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions.PMID 12173040Read ↗

Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process.Semantic proximity Read ↗

Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis.Semantic proximity Read ↗

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Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions.Semantic proximity Read ↗

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Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type.Semantic proximity Read ↗

Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.Semantic proximity Read ↗

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Semantic proximity Read ↗

Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors.Semantic proximity Read ↗

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