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Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process.

DNA repair - 1 Apr 2004

Nahari Dorit, McDaniel Lisa D, Task Laurie B, Daniel Russell L, Velasco-Miguel Susana, Friedberg Errol C

Abstract excerpt

Mutational hot spots in the human p53 gene are well established in tumors in the human population and are frequently negative prognosticators of the clinical outcome. We previously developed a mouse model of skin cancer with mutations in the xeroderma pigmentosum group C gene (Xpc). UVB radiation-induced skin cancer is significantly enhanced in these mice when they also carry a mutation in one copy of the Trp53...

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Source

Identifiers

PMID: 15010313
DOI: 10.1016/j.dnarep.2003.03.001

Genes

XPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process.PMID 15010313Read ↗

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