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Article

Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models.

DNA repair - 1 Nov 2012

van de Ven Marieke, Andressoo Jaan-Olle, van der Horst Gijsbertus T J, Hoeijmakers Jan H J, Mitchell James R

Abstract excerpt

XPD is a helicase subunit of transcription factor IIH, an eleven-protein complex involved in a wide range of cellular activities including transcription and nucleotide excision DNA repair (NER). Mutations in NER genes including XPD can lead to a variety of overlapping syndromes with three general categories of symptoms in addition to sun (UV) sensitivity: severe skin cancer predisposition as in xeroderma...

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Identifiers

PMID: 23046824
DOI: 10.1016/j.dnarep.2012.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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