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Article

Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.

Molecular biology of the cell - 1 Oct 2005

Meunier Frédéric A, Osborne Shona L, Hammond Gerald R V, Cooke Frank T, Parker Peter J, Domin Jan, Schiavo Giampietro

Abstract excerpt

Neurotransmitter release and hormonal secretion are highly regulated processes culminating in the calcium-dependent fusion of secretory vesicles with the plasma membrane. Here, we have identified a role for phosphatidylinositol 3-kinase C2alpha (PI3K-C2alpha) and its main catalytic product, PtdIns3P, in regulated exocytosis. In neuroendocrine cells, PI3K-C2alpha is present on a subpopulation of mature secretory...

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Identifiers

PMID: 16055506
DOI: 10.1091/mbc.e05-02-0171
PMCID: PMC1237087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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