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Article

Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator.

Biochimica et biophysica acta - 1 Apr 2011

Dasgupta Suman, Bhattacharya Sushmita, Maitra Sudipta, Pal Durba, Majumdar Subeer S, Datta Asis, Bhattacharya Samir

Abstract excerpt

Fatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating evidences suggest that one of the major sites of FAs adverse effect is insulin receptor (IR). However, the underlying mechanism is yet unclear. An important clue was indicated in leptin receptor deficient (db/db) diabetic mice where increased circulatory FAs was coincided with phosphorylated PKCε and reduced IR expression. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21236337
DOI: 10.1016/j.bbadis.2011.01.001

Genes

HMGA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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