Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator.

doi:10.1016/j.bbadis.2011.01.001

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Article

Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator.

Biochimica et biophysica acta - 1 Apr 2011

Dasgupta Suman, Bhattacharya Sushmita, Maitra Sudipta, Pal Durba, Majumdar Subeer S, Datta Asis, Bhattacharya Samir

Abstract excerpt

Fatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating evidences suggest that one of the major sites of FAs adverse effect is insulin receptor (IR). However, the underlying mechanism is yet unclear. An important clue was indicated in leptin receptor deficient (db/db) diabetic mice where increased circulatory FAs was coincided with phosphorylated PKCε and reduced IR expression. We...

Topics

Actins
Animals
Cell Line
Cell Nucleus
Down-Regulation
Enzyme Activation
Fatty Acids
HMGA Proteins
Humans
Insulin Resistance
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mutation

Palmitic Acid

Protein Kinase C-epsilon

Protein Transport

Rats

Source

Open in PubMed

Identifiers

PMID: 21236337
DOI: 10.1016/j.bbadis.2011.01.001

Genes

HMGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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