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Article

SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.

Blood - 1 Jan 2006

Ishikawa-Sekigami Tomomi, Kaneko Yoriaki, Okazawa Hideki, Tomizawa Takeshi, Okajo Jun, Saito Yasuyuki, Okuzawa Chie, Sugawara-Yokoo Minako, Nishiyama Uichi, Ohnishi Hiroshi, Matozaki Takashi, Nojima Yoshihisa

Abstract excerpt

The lifespan of circulating red blood cells (RBCs) produced in bone marrow is determined by their elimination through phagocytosis by splenic macrophages. The mechanism by which RBC elimination is regulated has remained unclear, however. The surface glycoprotein SHPS-1, a member of the immunoglobulin superfamily, is abundant in macrophages. We have now examined the regulation of RBC turnover with the use of mice...

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Identifiers

PMID: 16141346
DOI: 10.1182/blood-2005-05-1896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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