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Article

Regulation of multiple functions of SHPS-1, a transmembrane glycoprotein, by its cytoplasmic region.

Biochemical and biophysical research communications - 26 Sept 2003

Sato Ryuji, Ohnishi Hiroshi, Kobayashi Hisae, Kiuchi Daisuke, Hayashi Akiko, Kaneko Yuka, Honma Nakayuki, Okazawa Hideki, Hirata Yukio, Matozaki Takashi

Abstract excerpt

SHPS-1 is a receptor-type transmembrane glycoprotein, which contains four tyrosine residues in its cytoplasmic region, and the phosphorylation of these tyrosine residues serves the binding sites for SHP-2 protein-tyrosine phosphatase. Its extracellular region interacts with another membrane protein, CD47, thereby constituting a cell-cell communication system. We analyzed this ligand-receptor interaction using...

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Identifiers

PMID: 12963030
DOI: 10.1016/j.bbrc.2003.08.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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