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Article

Germ-line HER-2 variant and breast cancer risk by stage of disease.

Cancer research - 1 Dec 2001

McKean-Cowdin R, Kolonel L N, Press M F, Pike M C, Henderson B E

Abstract excerpt

HER-2 gene amplification and protein overexpression has been associated with increased risk of advanced-stage breast cancer and poor prognosis. Recently, a single missense point mutation (Ile(655)Val) in the transmembrane domain of the HER-2 gene was associated with a 40% increase in breast cancer risk among women 45 years of age and younger. In this analysis, we measured the association between the Ile(655)Val...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11731415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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