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Article

A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer.

Breast cancer research : BCR - 1 Jan 2005

Nelson Stephanie E, Gould Michael N, Hampton John M, Trentham-Dietz Amy

Abstract excerpt

BACKGROUND: Overexpression of the HER2 proto-oncogene in human cancer cells has been associated with a poor prognosis, and survival improves with therapy targeting the HER2 gene. Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization. METHODS: To...

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Identifiers

PMID: 15987431
DOI: 10.1186/bcr1004
PMCID: PMC1143556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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