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Article

EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance.

Molecular cancer therapeutics - 1 Oct 2008

Zhang Yuexing, Linn Douglas, Liu Zhenqiu, Melamed Jonathan, Tavora Fabio, Young Charles Y, Burger Angelika M, Hamburger Anne W

Abstract excerpt

Aberrant activation of the androgen receptor (AR) by the ErbB2/ErbB3 heterodimer contributes to the development of hormone resistance in prostate cancer. EBP1, an ErbB3-binding protein, acts as an AR corepressor. As EBP1 is decreased in preclinical models of hormone-refractory prostate cancer, we studied the expression of EBP1 in human prostate cancer. We found that the expression of the EBP1 gene was...

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Identifiers

PMID: 18852121
DOI: 10.1158/1535-7163.MCT-08-0526
PMCID: PMC2629587

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HRG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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