Article
A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells.
The Journal of biological chemistry - 24 Oct 2008
Li Hongyun, Xu Linda L, Masuda Katsuaki, Raymundo Eliza, McLeod David G, Dobi Albert, Srivastava Shiv
Abstract excerpt
PMEPA1 was identified originally as a highly androgen-inducible gene with prostate-abundant expression that was restricted to prostatic epithelial cells. PMEPA1 protein is a NEDD4 (ubiquitin-protein isopeptide ligase)-binding protein, which negatively regulates prostate cancer cell growth. In this study we establish that PMEPA1 is a direct transcriptional target of the androgen receptor (AR). We also demonstrate...
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