Article
Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells.
Oncogene - 28 Apr 2005
Berquin Isabelle M, Pang Bing, Dziubinski Michele L, Scott Latanya M, Chen Yong Q, Nolan Garry P, Ethier Stephen P
Abstract excerpt
The epidermal growth factor receptor (EGFR) is linked to poor outcome in breast cancer, and resistance to hormonal therapy is often accompanied by activation of growth factor receptors. To investigate the mechanism(s) by which EGFR becomes activated in breast cancer, we screened a cDNA expression library for genes that mediate EGF-independent proliferation of human mammary epithelial cells (HMECs). We isolated...
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