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Article

Transition to the open state of the TolC periplasmic tunnel entrance.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002

Andersen Christian, Koronakis Eva, Bokma Evert, Eswaran Jeyanthy, Humphreys Daniel, Hughes Colin, Koronakis Vassilis

Abstract excerpt

The TolC channel-tunnel spans the bacterial outer membrane and periplasm, providing a large exit duct for protein export and multidrug efflux when recruited by substrate-engaged inner membrane complexes. The sole constriction in the single pore of the homotrimeric TolC is the periplasmic tunnel entrance, which in its resting configuration is closed by dense packing of the 12 tunnel-forming alpha-helices....

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Share to Membrane Transport Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Bacterial Outer Membrane Proteins

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Source

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Identifiers

PMID: 12163644
DOI: 10.1073/pnas.162039399
PMCID: PMC123217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transition to the open state of the TolC periplasmic tunnel entrance.PMID 12163644Read ↗

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