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Article

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes.

Proceedings of the National Academy of Sciences of the United States of America - 5 Oct 2010

Egea Pascal F, Stroud Robert M

Abstract excerpt

The structure of the protein-translocating channel SecYEβ from Pyrococcus furiosus at 3.1-Å resolution suggests a mechanism for chaperoning transmembrane regions of a protein substrate during its lateral delivery into the lipid bilayer. Cytoplasmic segments of SecY orient the C-terminal α-helical region of another molecule, suggesting a general binding mode and a promiscuous guiding surface capable of...

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Identifiers

PMID: 20855604
DOI: 10.1073/pnas.1012556107
PMCID: PMC2951439

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Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes.PMID 20855604Read ↗

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