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Article

Gating at both ends and breathing in the middle: conformational dynamics of TolC.

Biophysical journal - 15 Dec 2008

Vaccaro Loredana, Scott Kathryn A, Sansom Mark S P

Abstract excerpt

Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore through the periplasmic space and the outer membrane. Molecular dynamics simulations of TolC have been performed, and...

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Source

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Identifiers

PMID: 18835894
DOI: 10.1529/biophysj.108.136028
PMCID: PMC2599845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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