Article
Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.
The EMBO journal - 16 Sept 2009
Bonsor Daniel A, Hecht Oliver, Vankemmelbeke Mireille, Sharma Amit, Krachler Anne Marie, Housden Nicholas G, Lilly Katie J, James Richard, Moore Geoffrey R, Kleanthous Colin
Abstract excerpt
The Tol system is a five-protein assembly parasitized by colicins and bacteriophages that helps stabilize the Gram-negative outer membrane (OM). We show that allosteric signalling through the six-bladed beta-propeller protein TolB is central to Tol function in Escherichia coli and that this is subverted by colicins such as ColE9 to initiate their OM translocation. Protein-protein interactions with the TolB...
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