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Article

Transitions between closed and open conformations of TolC: the effects of ions in simulations.

Biophysical journal - 22 Apr 2009

Schulz Robert, Kleinekathöfer Ulrich

Abstract excerpt

Bacteria, such as Escherichia coli, use multidrug efflux pumps to export toxic substrates through their cell membranes. Upon formation of an efflux pump, the aperture of its outer membrane protein TolC opens and thereby enables the extrusion of substrate molecules. The specialty of TolC is its ability to dock to different transporters, making it a highly versatile export protein. Within this study, the transition...

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Identifiers

PMID: 19383457
DOI: 10.1016/j.bpj.2009.01.021
PMCID: PMC2718315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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