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Article

Identification of VP1/2A and 2C as virulence genes of hepatitis A virus and demonstration of genetic instability of 2C.

Journal of virology - 1 Sept 2002

Emerson Suzanne U, Huang Ying K, Nguyen Hanh, Brockington Alicia, Govindarajan Sugantha, St Claire Marisa, Shapiro Max, Purcell Robert H

Abstract excerpt

Fourteen different chimeric virus genomes were constructed from two infectious cDNA clones encoding a virulent and an attenuated isolate, respectively, of the HM175 strain of hepatitis A virus. The ability of each recombinant virus to infect tamarins and to cause acute hepatitis was determined. Comparisons of the genotype and phenotype of each virus suggested that VP1/2A and 2C genes were responsible for...

Topics

Animals
Carrier Proteins
Cysteine Endopeptidases
Genotype
Hepatitis A
Hepatitis A virus
Mutation
Phenotype
Recombination, Genetic
Saguinus
Viral Nonstructural Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Proteins

Viral Structural Proteins

Virulence

Source

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Identifiers

PMID: 12163575
DOI: 10.1128/jvi.76.17.8551-8559.2002
PMCID: PMC136972

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