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Article

Identification of mutations in viral proteins involved in cell adaptation using a reverse genetic system of the live attenuated hepatitis A virus vaccine H2 strain.

Virologica Sinica - 1 Dec 2024

Yan Xiu-Li, Li Jian, Ma Qing-Qing, Wang Hong-Jiang, Li Lin, Zhao Hui, Qin Cheng-Feng, Li Xiao-Feng

Abstract excerpt

The live attenuated hepatitis A virus vaccine H2 strain was developed by passaging a wild-type H2w isolate in cell cultures. Currently, the mechanism underlying its attenuation phenotype remain largely unknown. In this study, we generated a full-length infectious cDNA clone of the H2 strain using in-fusion techniques. The recovered H2 strain (H2ic) from the cDNA clone exhibited an efficient replication in both...

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Identifiers

PMID: 39151705
DOI: 10.1016/j.virs.2024.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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