Article
An infectious cDNA clone of a cytopathic hepatitis A virus: genomic regions associated with rapid replication and cytopathic effect.
Virology - 1 Oct 1995
Zhang H, Chao S F, Ping L H, Grace K, Clarke B, Lemon S M
Abstract excerpt
Rapidly replicating, cytopathic (rr/cpe+) variants of hepatitis A virus (HAV) isolated from persistently infected BS-C-1 cells have numerous mutations from cell culture-adapted rr/cpe- HAV. To determine which mutations in one rr/cpe+ virus, HM175/18f, determine enhanced replication in BS-C-1 cell...
Topics
- Animals
- Base Sequence
- Cell Line
- Chlorocebus aethiops
- Cytopathogenic Effect, Viral
- DNA, Complementary
- DNA, Recombinant
- Hepatitis A Virus, Human
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- RNA, Viral
- Sequence Analysis, DNA
- Viral Proteins
- Virus Replication