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Article

2B and 2C mutations are essential but mutations throughout the genome of HAV contribute to adaptation to cell culture.

Virology - 1 Jun 1993

Emerson S U, Huang Y K, Purcell R H

Abstract excerpt

Chimeric viruses constructed from various portions of two infectious cDNA clones representing the genomes of the wild-type and cell culture-adapted mutants of the HM-175 strain of hepatitis A virus were compared for their ability to replicate in cultures of fetal rhesus kidney cells. Mutations located in either the 5' or 3' third of the genome could markedly enhance growth in vitro but only when they were...

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Identifiers

PMID: 8389072
DOI: 10.1006/viro.1993.1286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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