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Article

Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.

The Journal of biological chemistry - 4 Oct 2002

Shiojima Ichiro, Yefremashvili Mikkael, Luo Zhengyu, Kureishi Yasuko, Takahashi Akihiro, Tao Jingzang, Rosenzweig Anthony, Kahn C Ronald, Abel E Dale, Walsh Kenneth

Abstract excerpt

Akt is a serine-threonine kinase that mediates a variety of cellular responses to external stimuli. During postnatal development, Akt signaling in the heart was up-regulated when the heart was rapidly growing and was down-regulated by caloric restriction, suggesting a role of Akt in nutrient-dependent regulation of cardiac growth. Consistent with this notion, reductions in Akt, 70-kDa S6 kinase 1, and eukaryotic...

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PMID: 12163490
DOI: 10.1074/jbc.M204572200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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