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The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration

26 Dec 2021

Abstract excerpt

Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary...

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PMID: 35008660
DOI: 10.3390/ijms23010234

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