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Growth Factors, Nutrient Signaling, and Cardiovascular Aging

12 Apr 2012

Abstract excerpt

Growth factors regulated by specific macronutrients have been shown to promote aging and accelerate mortality in the majority of the organisms studied. In particular, the enzymes activated by growth hormone, insulin, and insulin-like growth factor-1 in mammals and their orthologs in simple model organisms represent perhaps the best-understood proteins involved in the aging process. Dietary restriction, which...

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PMID: 22499903
DOI: 10.1161/circresaha.111.246470

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