Article
Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.
Journal of neurochemistry - 1 Nov 2002
Milhavet Ollivier, Martindale Jennifer L, Camandola Simonetta, Chan Sic L, Gary Devin S, Cheng Aiwu, Holbrook Nikki J, Mattson Mark P
Abstract excerpt
Mutations in the presenilin-1 (PS1) gene cause early onset familial Alzheimer's disease (FAD) by a mechanism believed to involve perturbed endoplasmic reticulum (ER) function and altered proteolytic processing of the amyloid precursor protein. We investigated the molecular mechanisms underlying cell death and ER dysfunction in cultured cells and knock-in mice expressing FAD PS1 mutations. We report that PS1...
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