Staufen 1 amplifies proapoptotic activation of the unfolded protein response

Abstract excerpt

Abstract Staufen-1 (STAU1) is an RNA-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule-associated protein tau ( MAPT ), huntingtin ( HTT ), TAR DNA-binding protein-43 gene ( TARDBP ), or C9orf72. We previously reported that elevations in STAU1 determine autophagy defects and its knockdown is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Endoplasmic Reticulum Stress and Disease
• Share to Genetic Neurodegenerative Diseases