Article
Mif1: a missing link between the unfolded protein response pathway and ER-associated protein degradation?
Current protein & peptide science - 1 Jun 2001
van Laar T, van der Eb A J, Terleth C
Abstract excerpt
Eukaryotic cells have three different mechanisms to deal with the accumulation of unfolded proteins in the endoplasmic reticulum: (1) In cells in which unfolded polypeptides accumulate, translation initiation is inhibited to prevent further accumulation of unfolded proteins. (2) Expression of proteins involved in polypeptide folding is strongly enhanced by a process called the Unfolded Protein Response (UPR). (3)...
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