Article

Staufen 1 amplifies pro-apoptotic activation of the unfolded protein response

2019-10-28

Abstract excerpt

Staufen-1 (STAU1) is an RNA binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule associated protein tau ( MAPT ), huntingtin ( HTT ), TAR DNA-binding protein-43 gene ( TARDBP ) or C9orf72. We previously reported that elevations in STAU1 determine autophagy defects. Additional functional consequences...

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Literature Corpus work: 2d3cda84-ed47-57e3-9dbd-b80bf88eda80
DOI: 10.1101/820225

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