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Article

Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.

The Journal of biological chemistry - 11 Oct 2002

Baltzis Dionissios, Li Suiyang, Koromilas Antonis E

Abstract excerpt

The interferon-inducible double-stranded RNA (dsRNA)-activated protein kinase, PKR, plays an important role in messenger (m) RNA translation by phosphorylating the alpha subunit of eukaryotic initiation factor 2. Through this capacity PKR is thought to be a mediator of the antiviral and antiproliferative actions of interferon. In addition to translational function, PKR has been implicated in many signaling...

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PMID: 12161430
DOI: 10.1074/jbc.M203564200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.PMID 12161430Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

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Expression of human PKR protein kinase in transgenic mice.Semantic proximity Read ↗

Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Semantic proximity Read ↗

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon responseSemantic proximity Read ↗

PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways.Semantic proximity Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.Semantic proximity Read ↗

The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.Semantic proximity Read ↗

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.Semantic proximity Read ↗

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).Semantic proximity Read ↗

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