Article
Haplotype exclusion: the unique case presented by multiple immunoglobulin gene loci in cartilaginous fish.
Seminars in immunology - 1 Jun 2002
Eason Donna D, Litman Gary W
Abstract excerpt
Cartilaginous fish represent the most phylogenetically distant species from man in which immunoglobulin and T cell antigen receptor genes have been identified. Immunoglobulin genes in cartilaginous fish are organized in hundreds of clusters, located on different chromosomes and presumably are under independent regulation; large numbers of immunoglobulin gene clusters are germline-joined and thus their expression...
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