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Article

Immunoglobulin heavy chain exclusion in the shark.

PLoS biology - 24 Jun 2008

Malecek Karolina, Lee Victor, Feng Wendy, Huang Jing Li, Flajnik Martin F, Ohta Yuko, Hsu Ellen

Abstract excerpt

The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain locus. How allelic exclusion is regulated is unclear; we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18578572
DOI: 10.1371/journal.pbio.0060157
PMCID: PMC2435157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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