Article
fester, A candidate allorecognition receptor from a primitive chordate.
Immunity - 1 Jul 2006
Nyholm Spencer V, Passegue Emmanuelle, Ludington William B, Voskoboynik Ayelet, Mitchel Katrina, Weissman Irving L, De Tomaso Anthony W
Abstract excerpt
Histocompatibility in the primitive chordate, Botryllus schlosseri, is controlled by a single, highly polymorphic locus, the FuHC. By taking a forward genetic approach, we have identified a locus encoded near the FuHC, called fester, which is polymorphic, polygenic, and inherited in distinct haplotypes. Somatic diversification occurs through extensive alternative splicing, with each individual expressing a unique...
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