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Article

Allelic exclusion in anamniotic vertebrates.

Seminars in immunology - 1 Oct 1999

Hsu E, Lee S S

Abstract excerpt

Clonal selection, a central principle in immunology, is predicated on one lymphocyte making one kind of antibody or T cell receptor. At loci encoding antigen receptors only one allele is used, and this has been shown in normal lymphocytes from frogs to humans. Fish antibody chains, however, are encoded by multiple loci, and at some of these loci the gene segments are already rearranged in the germline. The...

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Identifiers

PMID: 10497087
DOI: 10.1006/smim.1999.0189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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