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Article

beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast.

Molecular biology of the cell - 1 Aug 2002

Gupta Mohan L, Bode Claudia J, Thrower Douglas A, Pearson Chad G, Suprenant Kathy A, Bloom Kerry S, Himes Richard H

Abstract excerpt

Microtubule dynamics are influenced by interactions of microtubules with cellular factors and by changes in the primary sequence of the tubulin molecule. Mutations of yeast beta-tubulin C354, which is located near the binding site of some antimitotic compounds, reduce microtubule dynamicity greater than 90% in vivo and in vitro. The resulting intrinsically stable microtubules allowed us to determine which, if...

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Identifiers

PMID: 12181356
DOI: 10.1091/mbc.e02-01-0003
PMCID: PMC117952

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