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Article

S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients.

Journal of neuropathology and experimental neurology - 1 Aug 2002

Hoyaux Daphné, Boom Alain, Van den Bosch Ludo, Belot Nathalie, Martin Jean-Jacques, Heizmann Claus W, Kiss Robert, Pochet Roland

Abstract excerpt

Astrogliosis is one of the earliest pathological changes observed in neurodegenerative diseases in general and in amyotrophic lateral sclerosis (ALS) in particular. ALS is characterized by selective degeneration of motoneurons. There are 2 forms of the disease: sporadic ALS (SALS), comprising 90%-95% of cases, and familial ALS (FALS), comprising 5%-10% of cases. FALS is an age-dependent autosomal dominant...

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Source

Identifiers

PMID: 12152788
DOI: 10.1093/jnen/61.8.736

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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